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KMID : 1134820190480111179
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Journal of the Korean Society of Food Science and Nutrition
2019 Volume.48 No. 11 p.1179 ~ p.1185
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Anti-Osteoarthritis and Anti-Arthrodynia Effects of a Mixture of Fermented Achyranthes japonica Nakai, Angelica gigas Nakai, and Eucommia ulmoides Oliver Extracts on Monosodium Iodoacetate-Induced Arthritis in Rats
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Choi Dong-Hwan
Jeong Hyun-Cheol
Kim Kyung-Min
Kwon Min-Young
Lee Seung-Hun
Sohn Jo-Hann
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Abstract
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Achyranthes japonica Nakai, Angelica gigas Nakai, and Eucommia ulmoides Oliver have been used as nutraceutical plants, and their anti-inflammatory functions have been demonstrated. This study evaluated the anti-osteoarthritis and anti-arthrodynia effects of a mixture of fermented A. japonica Nakai, A. gigas Nakai, and E. ulmoides Oliver extracts (FAAE). The monosodium iodoacetate (MIA)-induced osteoarthritis rat model was used, and the weight bearing index (WBI), proinflammatory cytokines, and histopathological examination were analyzed. Measurements of the weight-bearing index indicated that the administration of FAAE improved the weight-bearing distribution significantly. The levels of interleukin-1β and tumor necrosis factor-α in the blood were increased in the osteoarthritis-induced group but decreased in the group administered with FAAE. A histopathological examination of the cartilage showed that the osteoarthritis-induced group exhibited synovial hyperplasia and pannus formation, but the conditions were recovered significantly in the FAAE administered group. Therefore, FAAE is a potential agent to alleviate osteoarthritis.
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KEYWORD
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Achyranthes japonica Nakai, Angelica gigas Nakai, Eucommia ulmoides Oliver, osteoarthritis, arthrodynia
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